Liquid Chromatography (LC/HPLC)

In the inaugural installment of his new column, LCGC veteran Michael Swartz provides an overview of some of the newer LC technology used in contemporary LC laboratories.

This article describes methods to quantitatively analyse genotoxic and potentially genotoxic impurities in pharmaceutical ingredients

A fast clean and simple method to determine three organotin compounds in environmental samples is described

Kevin Schug talks to Harold McNair about his illustrious career in chromatography

Guest author Uwe Neue develops the principle of kinetic plots from scratch to make them more accessible to a wider audience.

The authors present the first installment in their examination of the basics of method validation.

In this installment of "Column Watch," Ron Majors looks at the results of a recent HPLC column survey conducted by LCGC North America.

Dionex Corporation (Sunnyvale, California) will be hosting a series of free seminars on liquid chromatography throughout the United States and Canada from September 9?October 29, 2009.

In Part II, we review MS ionization suppression; column, pH, and temperature selection; and system peaks and column equilibration issues associated with the use of five volatile perfluorocarboxylic acid reagents in LC.

What's the best way to integrate a peak?

Advion BioServices (Ithaca, New York) announced the expansion of its existing LC–MS Biomarker Services Group, which was launched in 2008 to develop and deliver customized assays for peptide, amino acid, lipid, neurotransmitter, and nucleotide biomarkers.

A novel way of separation for polyolefins.

How to determine PFCs in water by SPE-LC–MS.

John Dolan looks at the signal-to-noise ratio and its relationship to uncertainty in a measurment.

An optimization strategy to obtain the best possible performance in the shortest analysis time for comprehensive off-line 2D-LC.

This month's column discusses the type of problems one can encounter when using methods supplied to us by other.

How to improve chromatographic performance using ultrapure water

This work demonstrates gains of up to 7-fold in signal to noise ratio with APCI mass spectrometry and reduction in analysis times of 5- to 8-fold

LEAP Technologies and PerkinElmer have entered into a resale agreement that will allow the company to incorporate PerkinElmer?s UHPLC and HPLC technology into the front-end automation systems it provides.

Discover the advantages of using UHPLC–MS–MS for lactotripeptide analysis

October 2006. The authors demonstrate the use of multiple-injection affinity capillary electrophoresis (MIACE) and several variations to MIACE to determine binding constants between the glycopeptide antibotics vancomycin, ristocetin, and teicoplanin from Streptomyces orientalis, Nocardia lurida, and Actinoplanes teichomyceticus, respectively, and D-Ala-D-Ala terminus peptides.

LabLogic Systems have been chosen by the Department of Medical Physics and Clinical Engineering at Addenbroke's Hospital in Cambridge, UK to supply the equipment to support the department?s metabolite analysis system for early-phase PET studies.

Remember the Rule of One - change just one thing at a time

This article facilitates the selection of various perfluorocarboxylic acids as ion-pair reagents in LC.

Eksigent Technologies has announced that it will be stepping up its manufacturing capabilities by 40%, as well as expanding the company?s servicing capabilities, to meet demand for its HPLC products.