Gas Chromatography (GC)

This instalment examines the idea of stationary phase polarity in detail. The assumptions inherent in the most popular stationary phase polarity-evaluating systems—McReynolds constants and the polarity scale—are discussed.

Webinar Date/Time: Thu, Jan 19, 2023 11:00 AM EST

Small leaks may compromise column lifetime, increase maintenance, cause retention time shifts, and decrease sensitivity at elevated temperatures, but do they matter?

In this extended special feature to celebrate the 35th anniversary edition of LCGC Europe, key opinion leaders from the separation science community explore contemporary trends in separation science and identify possible future developments.

The ECD and its principles of operation are reviewed, and the general tradeoffs in detection between selectivity, ease of use, and sensitivity discussed.

In this extended special feature to celebrate the 35th anniversary edition of LCGC Europe, key opinion leaders from the separation science community explore contemporary trends in separation science and identify possible future developments.

Learning or mastering new skills as an adult can feel daunting. These three tips will help.

Webinar Date/Time: Mon, Dec 12, 2022 11:00 AM EST

Webinar Date/Time: Tue, Dec 13, 2022 11:00 AM EST

This month we interview Jessica Pandohee about her work in foodomics in prebiotics research for gut health, and the role of GC–O in aroma analysis for coffee-flavoured milk.

What’s the fastest way to acquire a new chromatographic skill? The answer lies with those who are just beginning to learn.

The electron capture detector (ECD) for GC is still used relatively unmodified today. But using it effectively means understanding the tradeoffs between selectivity, ease of use, and sensitivity.

In this instalment of “Practical GC”, air leaks in a gas chromatography (GC) system and their impact on GC stationary phases are examined.

When should multidimensional GC approaches be used for analyzing complex samples and analytes?

What’s the fastest way to acquire a new chromatographic skill? The answer lies with those who are just beginning to learn.

A broad range of trace-level volatile organic compounds was detected in drinking water using headspace–trap sampling.

It is a fact that most of us will be experiencing rising helium costs, and in some cases, caps on supply, or an inability to initiate new supply contracts from providers. Based on my own experiences, and those of colleagues and contacts, I’ve prepared what I hope is a succinct and focused guide on the factors one needs to evaluate to properly inform the decision to switch, and what to expect on the implementation journey.

Key insights on how to get the most out of gas chromatography for the most difficult problem solving, the best quantitative analysis, and the highest data integrity.

We pass on valuable lessons shared by the six GC speakers at ChromTalks 2022.

In this study, the experimental nontargeted screening approach and corresponding data analysis workflows—simultaneously using molecular ion information and structural information—are presented for the molecular identification and authenticity verification process from a brand perfume using GC–ecTOF-MS.

Professor James Ephraim Lovelock, inventor of the electron capture detector and developer of the Gaia theory, died last month on his 103rd Birthday.

An overview of modern approaches to small-molecule drug discovery.

This article provides an overview of the development and current status of comparative analysis for GC×GC–TOF-MS data and how key limitations can be overcome with a novel tile-based pairwise analysis method.

We might well ask “Where is gas chromatography (GC) heading?” For many analysts, the answer may be just “more of the same,” reflecting that GC is mature and that most analysis tasks and sample types have been tried and tested. In this scenario, any changes to the basic method may be marginal—sample introduction, and maybe a new detector? But beneath this status quo is an undercurrent of passion, excitement, and power.

Headspace GC reveals that sonication can degrade common organic solvents.