Liquid Chromatography (LC/HPLC)

A recent trend in the design of LC instrumentation is the move towards miniaturized and portable systems.

What are the options available when adjusting selectivity (peak spacing or elution pattern) when dealing with relatively simple mixtures?

Exploring the impact of green chemistry on analytical chemistry and GC is the focus of this instalment of "GC Connections".

This article covers LC columns and accessories commercially released after Pittcon 2022 through the 2023 conference held in Philadelphia, USA.

A rapid and robust LC–MS/MS method for determining lactulose and rhamnose concentrations in blood plasma was used to determine intestinal permeability from blood plasma, which can help diagnose gastrointestinal diseases such as Crohn’s disease.

The combination of an untargeted approach using ultrahigh pressure liquid chromatography–quadrupole time-of-flight mass spectrometry (UHPLC–QTOF) and a targeted approach using UHPLC–tandem mass spectrometry (MS/MS) are presented as an ideal method for detecting per- and polyfluroalkyl substances (PFAS) in fast-food packaging.

Scouting gradients can simplify LC method development. Here’s what you need to get started using them.

Our annual review of new liquid chromatography columns and accessories, introduced at Pittcon and other events over the past 12 months.

Everyone is talking about sustainability, and organizations are creating sustainability programs. But what does green chemistry really mean, and how does it apply to gas chromatography?

This method has greater sensitivity and a shorter LC analysis time than the AOAC method. It also requires less instrument maintenance, enhances column lifetime by requiring a smaller sample volume, and reduces cost by replacing acetonitrile with methanol in the mobile phase.

Selective pressurized liquid extraction and multilayer solid‑phase extraction methods are described for high‑throughput plant, soil, and water sample preparations. Optimal analytical conditions are described for the improvement of detection sensitivities and coverage. A Source Supported Suspect Screening (4S) approach is described; phytotoxins detected in the source plant were used to improve the identification of phytotoxins in soil and water.

Researchers have shown the effectiveness of ion chromatography (IC) in identifying markers of forest fire emissions in rainfall samples, providing valuable insights into the signature of forest fire emissions and aiding in the development of models to predict and control air pollution resulting from these events.

A new study has reported the preparation, characterization, and chromatographic evaluation of a nickel oxide deposited silica stationary phase in HILIC, which exhibited multiple retention mechanisms and enhanced chromatographic selectivity for analytes.

A new approach combining high performance liquid chromatography–mass spectrometry with ultrafiltration, along with enzyme channel blocking and directional enrichment, has been found effective for screening natural histidine decarboxylase inhibitors in Radix Paeoniae alba, while reducing both false-positive and false-negative results.

In the first of a two-part series, a recent study discusses a new strategy for assessing the peak purity of pharmaceutical peptides analysis using 2D-LC–MS.

Webinar Date/Time: Monday, May 22nd, 2023 Morning Session: 9am EDT | 6am PDT | 2pm BST | 3pm CEST Lunchtime Session: 1pm EDT | 10am PDT | 6pm BST | 7pm CEST Afternoon Session: 2pm EDT | 11am PDT | 7pm BST | 8pm CEST Tuesday, May 23rd, 2023 Morning Session: 9am EDT | 6am PDT | 2pm BST | 3pm CEST Lunchtime Session: 1pm EDT | 10am PDT | 6pm BST | 7pm CEST Afternoon Session: 2pm EDT | 11am PDT | 7pm BST | 8pm CEST

Glyphosate and AMPA are two potentially dangerous chemicals within herbicides. Using LC–MS to detect these chemicals is important to human and environmental health.

Using LC–MS, scientists have developed a new method for testing doping steroids in blood.

Combining liquid chromatography (LC) with high resolution mass spectrometry (HRMS) has led to incredibly detailed results in forensic drug screenings, though not without challenges.

Using an Analytical Quality by Design approach, scientists recently identified impurities in a pharmaceutical product for hypertension treatment.

Using liquid chromatography-tandem mass spectrometry, scientists have found a similarity between the protective functions of the oral permeability barrier and the skin barrier.

While pesticides may be beneficial, they may also cause health risks in foods. In a recent study, scientists created new methods for detecting maximum pesticide residue levels.

Dipeptide profiles have an important role in detecting disease, and a recent study has made it much more accessible to study them.

A new buffer management system that automates most processes will further how biopharmaceuticals are produced, helping save more lives in the process.

A recent study shows how 2D-LC–MS can provide expanded analytical coverage of cosmetics-prohibited substances.