Gas Chromatography (GC)

The trend towards dedicated analytical solutions continues to gain momentum while what might have been considered high performance instrumentation a few years ago are increasingly being viewed as routine techniques.

The instrument is "a splendid example of automatic analysis."

As environmental legislation becomes more stringent, the need to deliver quantitative results in shorter times and greater volumes is necessary for routine environmental analysis. Most of the high-throughput screening methods used to analyze pharmaceutical compounds are, however, useless for environmental monitoring. This is because these methods primarily aim to retrieve as much information from a single sample using the broadest range of techniques. The chromatographic separation process is considered to be the bottleneck in the process. This is not the situation for environmental procedures, in which the bottleneck is the sample preparation step and is usually very tedious and time-consuming.

This article discusses utra fast gas chromatography as a suitable technique for determining the hydrocarbon oil index in water. The advantages of this technique over conventional GC technology are presented.

A review of the latest products and innovations in gas chromatography to come out of Pittcon 2005.

Bob McDowall stresses the importance of using accurate and precise time and date stamps to ensure the integrity of the data and results generated by computerized systems in any chromatography laboratory.

John Hinshaw asks what constitutes a chromatographic method and addresses some of the issues that method transfer raises for method documentation and validation.

This month's installment of "Column Watch" is the conclusion of a two-part series in which Ron Majors examines the trends in column introductions at Pittcon 2005. Here, he discusses gas chromatography columns, sample preparation products, hardware, and accessories.

In this article, Jo Webber tackles the problem of ensuring data integrity in pharmaceutical manufacturing. She shows how, by using modern technology and well integrated systems, quality can be improved.

The authors explain how to construct box plots and how they can help you to learn more about your data.

Protease inhibitors are a class of anti-HIV drugs used in combination therapy to block replication of the HIV virus in a person's blood. It is important to monitor the levels of these drugs in the patient since resistance can develop at low levels and at high levels the drug can exhibit toxic effects.

Mini application notes summaries

In the concluding part of this series, the effects that column variability has on isothermal capillary gas chromatography is discussed and instrument calibration explored. The goal is to reduce the normal variability that occurs when working with multiple instruments and columns to ensure consistent results.

Pittcon 2005 - the 56th Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy - returned to the Orange County Convention Center, Orlando, Florida, 27 February-4 March 2005. This year's event hosted more than 900 instrument manufacturers and 1aboratory suppliers in more than 2300 booths. In addition to attending the exposition, the conferees were able to listen to numerous oral presentations, view more than 900 posters, check out 38 seminar rooms, or attend one of 150 short courses.

The authors discuss the issue of meeting the demands of regulatory compliance whilst ensuring good scientific practice. A number of requirements from 21 CFR Part 11 are cited to demonstrate the importance of applying the principles of risk analysis.

This month's installment of "Milestones in Chromatography" pays tribute to a true milestone in the evolution of chromatography: the introduction of the first successful GC instruments.

In this first of a two-part series, John Hinshaw discusses the relative effects that inlet pressures and oven temperatures have on capillary gas chromatography.

This column focuses on some of the latest developments in preparative-scale columns, bulk packing materials and column hardware designs. Silica, polymeric and other packings are discussed together with the newest monolithic columns.

This instalment of GC Connections examines the basics of peak identification and quantification and demonstrates how they can both influence the quality of one's results as much as or even more than sample preparation, separation and detection.

Maltodextrin is an easily digested carbohydrate made from corn starch...

VENTURE A affinity columns utilize ICEtechTM surface passivation technology...

Mini application note summaries...

Polymeric monolithic stationary phases offer an alternative to the classical microparticulate sorbents...

In response to a reader's question, John Hinshaw examines the effects on retention times and peak shapes when a retention gap is added to a capillary column.

This article is an adaptation of one written in the German publication Nachrichten aus der Chemie and discusses how gas chromatography instrumentation, columns and techniques have improved over the past 10–15 years, making even relatively new equipment obsolete for many applications. In particular, the authors look at how older equipment is unsuitable for fast GC, better trace analysis and comprehensive multidimensional GC.