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What’s the fastest way to acquire a new chromatographic skill? The answer lies with those who are just beginning to learn.

The LCGC Blog: Remember the First Time

Rachael Szafnauer received an M.Sci in forensic science from the University of South Wales, UK, where her final‑year project focused on fingerprinting emerging psychoactive substances using advanced techniques such as GC×GC–TOF MS, in collaboration with Markes International. She later took up the role of thermal desorption product specialist at Markes, providing technical and application support to the commercial team, before taking on her current role at the start of this year, specialising in the development of applications using extraction and enrichment techniques.


Elinor Hughes obtained her B.Sc. in chemistry and Ph.D. in organic chemistry at Bangor University, UK. After working for a chemical manufacturing company for three years, she moved to the Royal Society of Chemistry where she worked in journals publishing for six years and on Chemistry World magazine for four years. This was followed by five years as a freelance copyeditor and science writer. Her current role is technical copywriter at Markes International.

A broad range of trace-level volatile organic compounds was detected in drinking water using headspace–trap sampling.

Analysis of Volatile Organic Pollutants in Water Using Headspace–Trap GC–MS: Maximizing Performance for ppt‑Level VOCs

Tony Taylor is Group Technical Director of Crawford Scientific Group and CHROMacademy. His background is in pharmaceutical R&D and polymer chemistry, but he has spent the past 20 years in training and consulting, working with Crawford Scientific Group clients to ensure they attain the very best analytical science possible. He has trained and consulted with thousands of analytical chemists globally and is passionate about professional development in separation science, developing CHROMacademy as a means to provide high-quality online education to analytical chemists. His current research interests include HPLC column selectivity codification, advanced automated sample preparation, and LCâMS and GCâMS for materials characterization, especially in the field of extractables and leachables analysis.

It is a fact that most of us will be experiencing rising helium costs, and in some cases, caps on supply, or an inability to initiate new supply contracts from providers. Based on my own experiences, and those of colleagues and contacts, I’ve prepared what I hope is a succinct and focused guide on the factors one needs to evaluate to properly inform the decision to switch, and what to expect on the implementation journey.

The LCGC Blog: Hydrogen Carrier Gas for Gas Chromatography Mass Spectrometry (GC–MS) – a Practical Guide

Key insights on how to get the most out of gas chromatography for the most difficult problem solving,  the best quantitative analysis, and the highest data integrity.

Getting “Under the Hood” of Gas Chromatography: Lessons from the 2022 GC ChromTalks

We pass on valuable lessons shared by the six GC speakers at ChromTalks 2022.

Getting “Under the Hood” of Gas Chromatography: Lessons from ChromTalks 2022

In this study, the experimental nontargeted screening approach and corresponding data analysis workflows—simultaneously using molecular ion information and structural information—are presented for the molecular identification and authenticity verification process from a brand perfume using GC–ecTOF-MS.

Nontargeted Screening for the Verification of Allergenic Ingredients and Perfume Authenticity by GC-ecTOF-MS

Professor James Ephraim Lovelock, inventor of the electron capture detector and developer of the Gaia theory, died last month on his 103rd Birthday.

The LCGC Blog: In Appreciation of James Ephraim Lovelock, ECD Inventor, 1919–2022

An overview of modern approaches to small-molecule drug discovery.

Small-Molecule Drug Discovery: Processes, Perspectives, Candidate Selection, and Career Opportunities for Analytical Chemists

This article provides an overview of the development and current status of comparative analysis for GC×GC–TOF-MS data and how key limitations can be overcome with a novel tile-based pairwise analysis method.

New Perspectives on Comparative Analysis for Comprehensive Two-Dimensional Gas Chromatography

We might well ask “Where is gas chromatography (GC) heading?” For many analysts, the answer may be just “more of the same,” reflecting that GC is mature and that most analysis tasks and sample types have been tried and tested. In this scenario, any changes to the basic method may be marginal—sample introduction, and maybe a new detector? But beneath this status quo is an undercurrent of passion, excitement, and power.

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